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The key numbers to remember for prefilled semaglutide syringes: Refrigerated (2-8 degrees Celsius): stable for up to 28 days Room temperature (below 30 degrees Celsius): use within 7 days maximum Above 30 degrees Celsius: discard immediately Frozen: do not freeze prefilled syringes, as ice crystals can denature the peptide and damage the syringe barrel Step-by-step guide to prefilling semaglutide syringes safely If you have decided that prefilling makes sense for your situation, the process itself requires careful attention to sterile technique