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It also upregulates cardiac-enriched microRNAs, creating a vicious cycle involving abnormal myosin heavy chain expression, autophagy inhibition, and impaired mitochondrial fatty acid oxidation (Park et al., 2023)

For 2026, the maximum you can contribute is $4,400 for self-only coverage and $8,750 for family coverage (with an additional $1,000 catch-up contribution allowed if you are age 55 or older)