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Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222

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These findings position mTORC1 upstream of ISR signaling in this context

Research shows that taurine regulates mitochondrial protein synthesis, enhancing electron transport chain activity and protecting cells from excessive oxidative stress