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Sattar N, Lee M, Kristensen SL et al (2021) Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials
Stem Cells 33 (7), 23062319
Furthermore, based on preclinical evidence suggesting that muscle-derived IL-6 may enhance postprandial GLP-1 secretion [90], it has been proposed that GLP-1RAs could modulate metabolic and inflammatory processes through this pathway [39]
Clinical trials show that 25-40% of participants report gastrointestinal symptoms early on, but the vast majority find relief within 8-12 weeks as their system adjusts
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