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TRT may suppress natural testosterone production and affect fertility by lowering the sperm count GHS peptides can have a mixed influence on glucose metabolism by directly increasing insulin resistance, while indirectly lowering insulin resistance by increasing muscle mass

The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes