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The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]
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Combine that with people being told they can take the pill whenever means one day they might take it with food, another day on an empty stomach and that can and probably does lead to wild swings in drugs level in the blood, and if research has shown anything consistent with GLP-1 agonists it is that having big spikes and swings in drug levels tend to lead to increased side effects
Matching your injection day to your lifestyle The best injection day is the one that creates the least disruption and the most benefit
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