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As a water-soluble vitamin, B12 is crucial for the formation of red blood cells, contributing to oxygen transport and preventing anemia-related fatigue

10.1371/journal.pone.0213839 54 MellonS

ZDHHC12 is a negative regulator of NLRP3 activation, which catalyzes palmitoylation of NLRP3 at Cys844 (the corresponding site of mouse NLRP3 C841), thereby facilitating recognition of NLRP3 by heat shock cognate protein of 70 kDa (HSC70) to promote NLRP3 degradation via the chaperone-mediated autophagy (CMA) pathway, which prevents sustained inflammation