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However, the ileum cAMP levels were not affected by either T3 or MB07811 treatment in MMI mice (Supplementary Fig

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Rather, it is a benchmark rate that is based on the general trend toward increasing rates of sustained virologic response in recent years and the general appeal of using a fixed, clinically relevant threshold as a measure of treatment benefit.16 We determined that the enrollment of 500 patients in the sofosbuvir-velpatasvir group would provide a power of 90% to detect an improvement of at least 5 percentage points in the rate of sustained virologic response over the performance goal of 85%, on the basis of the two-sided exact one-sample binomial test at the 0.05 significance level