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NPY Neuron and IGF-1/Akt Pathway Activation Chronic systemic administration of GHRP-6 to normal adult rats increases IGF-1 mRNA and phosphorylated Akt (pAkt) levels in various brain regions including the hypothalamus with GHRP-6 specifically stimulating NPY and IGF-1 mRNA synthesis and activating Akt in neuropeptide Y neurons of the arcuate nucleus, suggesting that some of GHRP-6s effects involve stimulation of local IGF-1 production and Akt activation in NPY neurons

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Reported side effects are typically mild and may include: Mild nausea (usually with oral forms) Temporary dizziness Gastrointestinal discomfort Injection site reactions (with injectable form) Most users report no significant side effects, making it an attractive option for those concerned about adverse reactions to traditional medications

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