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Mutants affected in the transport and degradation of glutathione and glutathione S-conjugates did not exhibit differences in their susceptibility to AITC While glutathione is synthesized in the chloroplast and the cytosol it is also present in the mitochondrion, nucleus and the apoplast, indicating the necessity of transport 56

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As mentioned before, there is current clinical interest in using low dose estradiol therapy to treat antihormone resistant breast cancer [24] however only a minimal 30% of patients respond to this therapeutic strategy

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