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This means there is no established pharmacological mechanism by which semaglutide would be expected to cause spotting or bleeding between periods

In addition, plasma semaglutide levels were similar in dogs that had undergone pyloric ligation (to prevent intestinal absorption) compared with non-ligated dogs, and plasma concentrations in the splenic vein (draining the gastric cavity) were significantly higher than in the portal vein (draining the GI tract), further implicating the stomach as the site of absorption [56]

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