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conducted a cohort study including large and unselected populations with T2DM in Lombardy and Apulia (Italy) to evaluate the safety and efficacy profile of GLP-1RAs and SGLT-2 inhibitors vs other glucose-lowering drugs.36 The authors demonstrated a significant reduction in hospitalizations for PAD and lower limb complications in both cohorts on GLP-1RAs vs other antidiabetic agents
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Species that lacked either a GCG or GLP-1 sequence in the alignment were further removed to yield two final peptide sequence sets, each comprising 288 orthologous sequences
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