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Derived from epoxomicin, the , -epoxyketone moiety of carfilzomib binds to both the hydroxyl group and the free -amino group of Thr 1 in the catalytic 5 subunits, forming a morpholino adduct and blocking access of substrate proteins to the catalytic residues 77,78,79
van der Griend R, Biesma DH, Haas FJ, Faber JA, Duran M, Meuwissen OJ, and Banga JD (2000)
Skin glow refers to healthy, radiant, even-toned skin that reflects light well
If identity fields appear in different orders or different terminology across documents, transcription errors become more likely and reconciliation becomes slower
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