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Am J Physiol Gastrointest Liver Physiol
GSH deficiency results in the activation of von Willebrand Factor (Ibrahim et al., 2004) and in the accumulation of ROS, which affect clotting and platelet activation, impair endothelial function, and predispose to the risk of thrombotic events (Violi et al., 2017): notably, hypercoagulation is a prominent life-threatening complication in COVID-19 patients (Giardini et al., 2020)
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In a mouse model of peripheral neuropathic pain, DCA increased neuronal hyperexcitability dependent on TGR5 in DRGs 62
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