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Collectively, all GLP-1 receptor agonists, including native GLP-1, peptides, and small molecule GLP-1 receptor agonists, stabilize the binding pocket of the GLP-1 receptor in a similar fashion, which induces the TM helices 6 kink, a distinctive feature of the active state of the class B1 GPCR

2.5.7 Immunohistochemistry assay in vivo Paraffin-embedded skin tissue sections were routinely dewaxed and incubated with 3% HO in deionized water at room temperature for 25 min to eliminate endogenous peroxidase activity

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