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Prolonged exposure to supraphysiological doses of exogenous testosterone or synthetic anabolicandrogenic steroids (AAS) is associated with marked suppression of the hypothalamicpituitarygonadal (HPG) axis through negative feedback mechanisms that inhibit gonadotropin secretion (76)

The activation of GLP-1R is associated with glucose-induced insulin secretion and inhibition of -cell glucagon release [43]

1903 The Wright brothers achieve the first controlled, sustained powered flight, forever changing transportation and exploration

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