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The t 1/2 of Exendin-4-Fc was 133.92 25.1 h (0.1 mg/kg) and it could be detected for more than 12 days after a single injection (Fig
To examine the similarity of peptides predicted by different models within each potency profile, we used PCA, considering the 500 one-hot-encoded sequences generated across all five compared models, the wild-type peptideshGCG and hGLP-1and their single-step mutants (551 hGCG and 570 hGLP-1), such that the projection was computed for an array [1,621 21 L ]
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