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Peripheral inflammation enhances microglia response and Nigral dopaminergic cell death in an in vivo MPTP model of Parkinson's disease

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Gene Expression Modulation Transcriptomic analyses in cellular models have shown that GHK-Cu influences expression of a remarkably wide set of genes, with reported effects on pathways involved in: Extracellular matrix remodeling DNA repair Antioxidant response Inflammatory signaling Stem cell signaling markers This broad transcriptional footprint has been one of the most studied aspects of GHK-Cu in recent years

We sought to investigate whether the anti-inflammatory effect of AST is due to the regulation of macrophage phenotypic transition and the modification of the immune microenvironment in wounds (Fig