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Munkholm K, Braner JV, Kessing LV, Vinberg M

Bcl-2 and OGC appear to act in a coordinated manner to increase the mGSH pool and to enhance the resistance of neurons to mitochondrial oxidative stress

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The upregulation of interferon-stimulated gene 15 in TECs disrupted mitochondrial homeostasis and triggered the release of mtDNA into the cytosol, which then triggers NLRP3mediated pyroptosis in cyclic GMP-AMP synthase-stimulator of interferon genes pathway (47)