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Adding 4mL creates a 5mg/mL concentration
Unlike small molecule drugs, peptides have unique dose-response characteristics: U-shaped dose-response curves are common (BPC-157, GHK-Cu) higher doses may paradoxically reduce efficacy Narrow therapeutic windows in certain peptides (cagrilintide at high doses can cause significant GI effects in animal models) Non-linear bioavailability SC and IP absorption does not scale linearly with concentration
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Ser-9 is conserved in epsilon, delta, theta, and unclassified GSTs and works to stabilize the GSH thiolate through a hydrogen bonding interaction [42, 73, 80, 83, 84, 86]
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