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Recent analyses comparing GLP-1 medications to bariatric surgery have found surgery to offer better value in certain populations, despite its invasive nature

The deleterious mechanisms activated during the ischemia and reperfusion phases in MI include oxygen deprival, decreased availability of nutrients and survival factors, accumulation of waste products, generation of oxygen free radicals, calcium overload, neutrophil infiltration in the ischemic area, depletion of energy stores, and opening of the mitochondrial permeability transition pore, all of them contributing to activation of apoptosis and necrosis in cardiomyocytes

Combined these data provide novel insight into the therapeutic actions of HGF/MET activation to ameliorate cognitive deficits after repeated mTBI

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