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53, 9991012.10.1111/j.1365-313X.2007.03389.x 52 PolekhinaG.BoardP
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Additionally, in Sprague-Dawley rats with PVAT dysfunction induced by a high-fat diet (HFD), exercise training promotes the transcriptional activation of BMP4 and its related signaling components in PVAT, such as p38/MAPK, PGC-1, and Smad5, which increases the BMP4 protein content in PVAT and activates downstream signaling pathways, thereby facilitating the browning of PVAT
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