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If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day
13th ed
Clinically significant portal hypertension events were defined as the first occurrence of esophageal varices (i.e., with and without bleeding), gastric varices, ascites, hepatic failure, hepatorenal syndrome, portal hypertension, liver transplant status, fibrosis and cirrhosis of liver, hepatic encephalopathy, jaundice, and chronic passive congestion of liver
So the oxidation is happening inside our body all the time
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