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Katzenstein AL, Bloor CM, Leibow AA
doi: 10.1007/s00125-023-05988-3 146
Every time people have studied nutrient sensing, weve learned a lot about biology, and many drugs have been developed as a result. Antioxidant power Glutathione is an antioxidant produced throughout the body that plays many important roles, including neutralizing unstable oxygen molecules called free radicals, which cause damage to DNA and cells if left unchecked
The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions
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