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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) ( 2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

Without diet and exercise, any effect of the injection would be minimal

PTH stimulates osteoclast differentiation and survival and calcium release from the bone matrix when serum calcium levels are low