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Decreased aging, improved performance that are attributable to improved blood pressure control, improved glycemic control, weight loss, increased renal blood flow, restoration of normal glomerular hemodynamics, enhanced autoregulation, and prevention of oxidative injury are potential contributors to reducing cardiovascular events through the kidney-cardiovascular axis [85]
Male subjects may experience transient erectile effects at doses above 1mg due to MC4R activation in peripheral vascular smooth muscle
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