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The FDA's 2024 review discussed free-base and acetate forms but did not set a standard acetic-acid mixing instruction

A randomized controlled trial in 167 older adults (50 years) found two-year supplementation with vitamin B 12 (10 g/day), along with folic acid (200 g/day), vitamin B6 (10 mg/day), riboflavin (5 mg/day), and vitamin D (10 g/day), had no effect on bone mineral density (total hip, femoral neck, or lumbar spine) compared to the control group only receiving vitamin D (10 g/day ) (116)

Slight lethargy initially: Counterintuitive given that AOD 9604 eventually improves energy, but some users feel slightly tired during the first few days