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Mediation analysis from the STEP trials found that of the additional 7.6-14.4% weight loss achieved with semaglutide versus placebo, less than 1 percentage point was mediated by gastrointestinal adverse events
The aforementioned research by Hefferman et al has also indicated that Frag 176-191 may substantially support fatty acid oxidation rates, particularly noted in models of obesity, where fat oxidation reportedly increased by as much as 216%
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