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Binding at this receptor triggers intracellular calcium signaling cascades in somatotroph cells of the anterior pituitary, leading to growth hormone release in a pulsatile pattern that mimics physiological secretion in animal models

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There are two forms commonly referenced in the literature: CJC-1295 with DAC (Drug Affinity Complex), which has a half-life of approximately 68 days, and CJC-1295 without DAC (also called Modified GRF 1-29), which has a much shorter half-life

Recipient mice livers were harvested at various time points to monitor transplantation and repopulation