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A landmark study published in PNAS demonstrated that Akkermansia muciniphila interacts directly with the intestinal epithelium and that, in animal models, administering this bacterium reversed key markers of diet-induced obesity, including fat mass gain, metabolic inflammation, and gut barrier disruption
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After propensity-score matching, the two cohorts (504 in each cohort, mean age 46.1 years, 57.5% women, 26.4% black, 54.7% white, 6.7% Hispanic) were balanced (see Supplementary Table S2 in the Supplementary Appendix)
The incidence of selected gastrointestinal adverse reactions in patients treated with Januvia was as follows: abdominal pain (Januvia 100 mg, 2.3%
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