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During anaplerosis, mitochondrial glutamate dehydrogenase 1 (GLUD1) plays a key role by catalyzing the conversion of glutamate to alpha-ketoglutarate (-KG) and releasing ammonia, which regulates autophagy and neutralizes the intracellular pH in cancer cells 19,20
This dual effect on appetite regulation and glucose metabolism makes them effective for both weight loss and type 2 diabetes management
the drugs work by modulating appetite, regulating blood sugar, and slowing gastric emptying
UK Biobank data are available through a procedure described at Registered researchers whose institutions have Data Use and Registration Agreements in place with All of Us that include the Controlled Tier can access genomic data
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