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Addressing issues like cataracts, glaucoma, or dry eye before starting the medication leads to better outcomes overall

Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage

It is important to distinguish between dark urine caused by concentration (which appears deep yellow to amber and clears with increased fluid intake) and abnormal pigmentation suggesting pathology (such as tea-coloured urine indicating bilirubin, or red-brown urine suggesting blood or myoglobin)

These effects are dose-dependent, meaning they often become more noticeable when the dose is increased during the titration phase