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For example, a decade of clinical trials have revealed that the seemingly antagonistic therapeutic combination of bortezomib (anti-proteolytic) and IMiDs (pro-proteolytic) confers a favorable prognosis compared with either alone 104,105

Am J Health Syst Pharm 70(17):14831494

At monthly follow up visits, the semen analysis of the treated group showed recovery of motile sperm in the ejaculate at concentration of 4.0 million/ml, while the untreated groups remained unchanged