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The local nutritional climate is mediated by mTOR to regulate cell growth, differentiation, metabolism, and autophagy [17]

Key end points included: hospitalisation, heart failure (ICD-10-CM-I50), myocardial infarction (ICD-10-CM-I21), stroke and transient ischaemic attack (ICD-10-CM-I63, G45), development of diabetic microvascular complications (ICD-10-CM-E10.210.4) and all-cause mortality analysed 3 months to 5 years post drug initiation

In the year 2020, cataracts and glaucoma affected over 15 million and 3 million adults aged over 50, respectively, emerging as the predominant causes of blindness on a global scale [2]