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This early BBB dysfunction and glymphatic system impairment may contribute to the initiation of neurodegenerative processes such as those seen in Alzheimer's disease (Sweeney et al., 2018)

Synthetic pineal tetrapeptide activating hTERT (telomerase reverse transcriptase) expression in somatic cells, reducing oxidative stress markers (MDA, SOD, catalase), and restoring melatonin circadian amplitude in aged models

Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha