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Encouragingly, there may now be a better solution than any of these three hacks. Novo Nordisks Wegovy pill, an oral form of semaglutide, was FDA-approved in December 2025 and launched in January 2026

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Among the developed prodrugs, the lack of activity was confirmed only for D-glucose-conjugated prodrug of 7-chlorokynurenic acid (133, 134), glycosyl prodrugs of dopamine (135) and ibuprofen prodrugs (145)

If its phase 3 trials confirm the phase 2 results, we may soon have a medication that rivals the effectiveness of bariatric surgery in a simple weekly injection