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This adaptive response, however, comes with a caveat: it leads to a decline in intracellular GSH synthesis, which in turn impacts the biological activity of GPX4, a key enzyme in preventing lipid peroxidation and ferroptosis [24]
The body is forced to switch to inefficient, anaerobic (oxygen-free) energy production, which generates lactic acid and further exacerbates systemic pain and fatigue
The role of oxidative stress in tumorigenesis and progression
Its forgiving side-effect profile means no appetite disruption during adaptation
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