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frequent abnormalities include impaired relaxation of the proximal stomach, reduced antral contractility and abnormalities of the gastric electrical rhythm [3, 6]
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Importantly, GLP-1 and glucagon act through structurally related receptors and both peptides exhibit similar amino acid N-terminal sequences, a domain essential for proper interaction with their receptors
However, native GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) and cleared renally, resulting in a plasma half-life of approximately 23 min [20, 21]
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