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Initially, studies reflected on how social media would change public health [35] but gave little thought to the possible deleterious effects of social media on public health

That doesnt include the extra time required if Health Canada needs more information from the drug company

El Diabetes Prevention Program, el ensayo de referencia en este campo, mostr que la metformina redujo en 31% la progresin a diabetes en personas de alto riesgo (frente a 58% con cambios de estilo de vida intensivos), y a 15 aos de seguimiento mantuvo una reduccin del 18% en la incidencia de diabetes, sin seales de seguridad relevantes a largo plazo (Diabetes Care, DPPOS)