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Medical Agencies from many around the world that have added PSSD warnings include: European Medical Agency (2019) HPRA in Ireland (2019) MHRA in the UK (2019) Health Canada (2021) Hong Kong Dept of Health (2022) Australian Dept of Health (2024) Malaysian Pharmaceutical Regulators (2025) As of December 2025, FDA regulators have kept PSSD warnings hidden from the public, although information letters about PSSD risks associated with antidepressants were sent back in 2019

Penetration of interleukin-6 across the murine blood-brain barrier

This damage impairs the metabolic adaptability required for CD4 + T cells to differentiate into Tregs, forcing a shift toward the Th17 phenotype (78) and contributing to Treg functional exhaustion