Retatrutide's proposed mechanism of action involves GLP-1 receptor activation to slow gastric emptying and promote satiety, GIP receptor activation to support insulin secretion and adipose tissue regulation, and glucagon receptor agonism, which in trial settings has been associated with increased energy expenditure and lipolysis
van der Velpen V, Teav T, Gallart-Ayala H, Mehl F, Konz I, Clark C, et al
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NCSL Resources on GLP-1 Drugs Prescription Drug Legislation Database Prescription Drug Policy Resource Center The Debate Over Weight-Loss Drugs Diabetes State Mandates and Insulin Copayment Caps The average annual list price of GLP-1s is $12,000 and, according to a Peterson-KFF tracker, most large employer health plans restrict coverage for weight loss