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The three drugs were known to have low oral bioavailability and expected to also have low nasal bioavailability, because it has been shown [13] that drugs such as mometasone furoate, fluticasone propionate and fluticasone furoate have low nasal bioavailability ( 10 m) and small ( 65% with a mass median aerodynamic diameter of approximately 1m
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NAC potentially reduces the harmful effects of reactive oxygen species by direct scavenging of radicals and supplying cysteine for enhanced glutathione synthesis
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