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These data suggest that NRF2 activation following GSH depletion causes repression of LXR activity, leading to lower expression of lipogenic enzymes and lower levels of serum triglycerides
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Separately, another study suggested that longer durations of GLP-1RA treatment may help sustain weight loss even after discontinuation, although this hypothesis remains to be validated
The pathological changes could also include altered brain metabolism, excitotoxicity, free radical generation, neuroinflammation, blood-brain barrier dysfunction, and apoptosis
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