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Clin Endocrinol (2009) 71(4):5006
Translational superiority of GLP-1R/GCGR dual agonism versus GLP-1R on the body weight benefit was later demonstrated in obese rhesus monkeys (47, 48) and confirmed by other groups (49)
This provides a theoretical basis for uncertainty management, serving as a crucial caveat for clinicians: when utilizing GLP-1RAs, one must distinguish between the relative certainty of metabolic benefits and the stochastic nature of reproductive improvements
Collagen hydrolysates (composed of dipeptides and tripeptides), thought to be resistant to peptidase activity during digestion [27, 29], can enter the blood and be subsequently transported to the skin to yield positive effects on hydration and elasticity and improve wrinkles, particularly in aging women [26,27,28,29, 31]
