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Buprenorphine Dextromoramide Diamorphine (heroin) Fentanyl and its derivatives Hydromorphone Methadone Morphine Nicomorphine Oxycodone Oxymorphone Pentazocine Pethidine Tramadol S8 CANNABINOIDS In competition All prohibited substances in this class are Specified Substances

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Research links these syndromes with: Immune dysregulation Mast cell activation Neuroinflammation Small fiber neuropathy Autonomic dysfunction Gastrointestinal dysmotility Mast cells central to MCAS release: Histamine Tryptase Prostaglandins Leukotrienes Cytokines These mediators drive self-reinforcing neuroimmune signaling loops , amplifying inflammation throughout the body (Theoharides et al., 2012)

DOI: 10.1016/j.mito.2024.101877 Enhanced Mitochondrial Mrs2-Mg2+ Signaling Drives Mitochondrial Dysfunction in Pulmonary Arterial Hypertension Rats by Ruo-Nan Chen, Xue-Qin Weng, Yan Yan, Qin-Ye Chen, Yi-Chen Lin, Lan Liu, Xiao-Ling Zhuang, Long-Xin Gui, James S.K