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Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise
Treatment options may include rest, wrist splints, medications, or even surgery
Further, activation of the NLRP3 cascade promotes RF through RTEC pyroptosis ( SalB enhances the nuclear accumulation of Nrf2 and suppresses NLRP3 activation, oxidative stress, and Caspase-1/Gasdermin D-mediated cellular pyroptosis via the Nrf2/NLRP3 pathway (Pang et al., 2020)
Organoids also contribute to immune response studies, especially for investigating immunekidney interactions (51), and are promising tools for bioartificial kidney systems via integration with microfluidic platforms (52)
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