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NCT04847557) seeks to evaluate the effect of tirzepatide (is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors) over 52 weeks in 700 patients with heart failure with preserved ejection fraction (HFpEF) and obesity
However, increasing structural and compositional complexity introduces challenges related to long-term safety evaluation, regulatory approval, and reproducible manufacturing, highlighting the need for rigorous validation frameworks [183]
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