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You should only take a drug off-label if your doctor gives you a full exam, knows your medical history, and thinks its a good idea for you, says Pichamol Jirapinyo, MD, MPH, an assistant professor of medicine at Harvard Medical School in Boston and cofounder of Everself

It says a headache warrants evaluation if it continues beyond week six, gets worse as the dose escalates, or arrives alongside vision changes, severe nausea, or chest discomfort

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