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Design stacks with clear protocols for dosing, timing, cycling, start low, titrate to response, time around workouts and sleep, and off-cycle to minimize tolerance and long-term risk
They reported generally mild, transient adverse effects and inconsistent but sometimes positive effects on depression, anxiety, and anhedonia, while outcomes in substance use disorders were mixed
However, due to limitations in methodology and potential bias, the certainty of the evidence is low
Month 1 : You feel less hungry and start managing portions better
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