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in countries like India, stricter law and active courts can cut these fences down earlier.[22][20] 5.4 Global Pricing and Access Management Highincome markets (US, EU, some Gulf countries) bear the highest list prices and drive most of the profit.[17][18] Middleincome countries often see delayed launches, tight quotas or premium pricing , as companies try to avoid price erosion leaking back into rich markets through reference pricing.[28][18][21] Key point: The science may be global, but the business model is finely tuned country by countryusing brands, patents and pricing to stretch the profitable life of the molecule